Max Planck Institute for Dynamics and Self-Organization -- Department for Nonlinear Dynamics and Network Dynamics Group
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BCCN/BFNT AG-Seminar

Tuesday, 18.05.2010 17 c.t.

Modelling of the Switching between Network States in Hippocampal Area CA3

by Dr. Anastasia Lavrova
from Fakultät für Physik, Humboldt Universität zu Berlin

Contact person: Vitaly Belik

Location

Seminarraum Haus 2, 4. Stock (Bunsenstr.)

Abstract

Hippocampus is required for the encoding of new information [1] and plays an important role in spatial navigation. Spatial information is coded at theta frequencies (4-12 Hz) by neurons distributed along longitudinial axis of the hippocampus. Gamma oscillations (30-80 Hz) are generated by the hippocampus and involved in information transmission and storage. Hippocampus consists of several parts (EC, DG, CA1, CA3, CA2). It has been experimentally shown that neuronal network in area CA3 can exhibit both theta- and gamma- oscillations and dynamically switch between them It was shown earlier that this switching is controlled by the synaptic conductance between interneurons (basket- and O-LM cells) and pyramidal cells. The minimal network scheme, describing connections between different types of cells and its detailed model have been studied in [1,2]. We construct a simple model based on the scheme suggested in [1], which reproduces important physical characteristics of the oscillations of all cells types: the period, amplitude and phase shift. This model allows to analyze an influence of synaptic connections between cells on the mention characteristics. Supported by BCCN Proejkt A3 [1] Gloveli T., Dugladze T., Rotstein H., Traub R., Monyer H., Heinemann U., Whittington M., Kopell N., PNAS, V.102 13295-300 (2005) [2] Tort A., Rotstein H., Dugladze T., Gloveli T., Kopell N., PNAS, V.104, 13490-95 (2007)

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