Max Planck Institute for Dynamics and Self-Organization -- Department for Nonlinear Dynamics and Network Dynamics Group
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Tuesday, 22.06.2010 17 c.t.

The dynamic architecture of the cortex during development and after lesions

by Prof. Dr. Siegrid Löwel
from Institute of General Zoology and Animal Physiology, Friedrich-Schiller-University Jena

Contact person: Tatjana Tchumatchenko


Seminarraum Haus 2, 4. Stock (Bunsenstr.)


Being interested in brain plasticity my group and I investigate the mechanisms underlying changes in nerve cell networks i) during early postnatal development, ii) during adulthood, iii) more recently also during ageing and iv) after lesions. As model systems, we investigate network changes in the visual system, initially in cats and ferrets and in the last 5 years also in mice. Our aims are to understand mechanisms underlying changes in nerve cell networks and to help to develop strategies/therapies to improve compromised neuronal plasticity in the ageing or injured brain. In the first part of my talk, I will present data showing that a particular kind of connections in the visual cortex, the so-called long-range horizontal connections, are modified by strabismic amblyopia and hypothesize that these network changes underlie the modified perceptual capabilities of amblyopes. In the second part of my talk, I will present our recent work on neuronal plasticity in mice and discuss both experience- and age-dependent changes of visual cortical plasticity and sensory learning in healthy animals and after a cortical stroke.


Bernstein Lecture Series 2010

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