Max Planck Institute for Dynamics and Self-Organization -- Department for Nonlinear Dynamics and Network Dynamics Group
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BCCN AG-Seminar

Wednesday, 20.01.2010 17 c.t.

Neurotherapies R&D at Philips Research

by Prof. Dr. Michel M.J. Decré
from Health Care Devices and Instrumentation Department, Philips Research Eindhoven, The Netherlands

Contact person: Theo Geisel

Location

Seminarraum Haus 2, 4. Stock (Bunsenstr.)

Abstract

Michel Decré has lead the novel research programme on neurostimulation at Philips Research since 2005. In November 2008, Philips Research and NeuroNexus Technologies Inc. announced that they had joined forces to develop next-generation deep brain stimulation (DBS) devices with the ambition to improve the treatment of neurological diseases and psychiatric disorders. Our initial research aims to meet the functional requirements of a deep brain stimulation device for the treatment of Parkinson’s disease. We will introduce some of the salient features of our DBS prototype, comprising a multi-channel stimulation and recording system with a DBS multi-electrode array, which we envision as a tool that will enable field steering and closed-loop neurostimulation in the future. Next to our technology development, we also run a programme for a better understanding of the mechanisms of deep brain stimulation. To this end, we are developing microfabricated chambers for the in-vitro culture of neurons in communicating compartments. The final objective of this activity is to build and study in-vitro networks of differentiated neurons, mimicking in vivo connectivity while allowing unprecedented experimental control and access to the network. Initial two-compartments cultures of cortical neurons and their recordings indicate cross-compartment connectivity, allowing to set the next step towards differentiated cultures.

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