Max Planck Institute for Dynamics and Self-Organization -- Department for Nonlinear Dynamics and Network Dynamics Group
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BCCN AG-Seminar

Tuesday, 28.10.2008 17:15 c.t.

Nonequilibrium dynamics of protein amyloid self-assembly

by Dr. Chiu Fan Lee
from Physics Department, Clarendon Laboratory, Oxford University, UK

Contact person: Theo Geisel

Location

Seminarraum Haus 2, 4. Stock (Bunsenstr.)

Abstract

Amyloid fibrils are a form of protein aggregates that are stabilised by an array of hydrogen bonds and hydrophobic interactions. They are intimately related to many human diseases including the Alzheimer's disease and type II diabetes. In this talk, I will discuss the various physical properties of amyloid fibrils by starting with their thermodynamic stability. I will then present a theory on fibril breakage based on Kramers escape problem, and some results on the study of fibril elongation based on coarse-grained molecular dynamics simulations. I will end by discussing the process of nucleation for amyloid formation.

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