Max Planck Institute for Dynamics and Self-Organization -- Department for Nonlinear Dynamics and Network Dynamics Group
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BCCN AG-Seminar

Tuesday, 23.05.2006 16 c.t.

Adult cortical plasticity - reality or methodical artefact?

by Prof. Dr. Ulf Eysel
from Abteilung für Neurophysiologie, Ruhr-Universität Bochum

Location

Seminarraum Haus 2, 4. Stock (Bunsenstr.)

Abstract

Neurons in the mature visual cortex, when deprived of their normal retinotopic inputs by retinal lesions, are silenced but become reactivated with time when the initially “blind” cortical region (lesion projection zone) is filled-in by new suprathreshold visual responses with a remapped retinotopy. This phenomenon of adult cortical plasticity has been discovered on the basis of single cell recordings, but was challenged by recent fMRI results. We present our new results that reveal a characteristic pattern of spatio-temporal dynamics with transient hyperexcitability and a differential potential for recovery of simple and complex neuronal properties during long-term cortical reorganization of suprathreshold neuronal responses. The discrepancy between single electrode and fMRI imaging results will be adressed and explained.

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