Max Planck Institute for Dynamics and Self-Organization -- Department for Nonlinear Dynamics and Network Dynamics Group
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BCCN Sonderseminar

Friday, 08.09.2006 14 c.t.

Interdependency of dentate neurogenesis and synaptogenesis in experiment and simulation

by Markus Butz
from Deptartment of Neuroanatomy, University of Bielefeld

Location

Seminarraum Haus 2, 4. Stock (Bunsenstr.)

Abstract

We propose a biological network model to describe neurogenesis and synaptogenesis in the hippocampal denatate gyrus as interdependent processes. Simulating the synaptic reorganisation process among proliferating and pre-existing neurons by our network model predicts an optimal synaptogenesis for a moderate cell proliferation whereas an increased cell proliferation leads to a reduced synaptogenesis. This effect is also observed experimentally in the dentate gyrus of gerbils: Impoverished in contrast to semi-naturally reared animals are known to have a permanently increased dentate cell proliferation in adulthood. Our recent quantitative immun-histochemical data now proofs a significantly reduced synaptogenesis – quantified by the densitiy of lysosomal processes in the DG. Furthermore, impoverished reared gerbils juvenilely intoxicated with a single high dose methamphetamine have again low cell proliferation rates in adulthood. In accordance with the theoretical predictions, these animals also have significantly enhanced synaptogenesis compared to non-treated impoverished reared animals. Thus, the experimental data strongly support the theoretical explanation model and certifies a causal dependency of CP and synaptogenesis in the dentate gyrus of the rodent brain.

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