Max Planck Institute for Dynamics and Self-Organization -- Department for Nonlinear Dynamics and Network Dynamics Group
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BCCN AG-Seminar

Tuesday, 15.05.2007 17 c.t.

Sodium fluxes and excitability of thin neuronal processes

by Dr. Ilya Fleidervish
from Hebrew University of Jerusalem, Israel

Contact person: Fred Wolf

Location

Seminarraum Haus 2, 4. Stock (Bunsenstr.)

Abstract

In order to understand the complex, non-linear mechanisms that underlie neuronal excitability, it is critical to know the precise behavior of the axonal and dendritic Na+ channels. Here, we explored this behavior using a combination of patch clamp recording, high-speed Na+ imaging and computer simulations. We found that, in layer 5 pyramidal neurons, the axonal Na+ channels density is ~3 times higher than in the soma and ~30 times higher than in the basal dendrites. At functionally critical subthreshold voltages, persistent Na+ conductance in these neurons is predominately axonal, and it reflects activation of a remarkably high percentage of Na+ channels.

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