Max Planck Institute for Dynamics and Self-Organization -- Department for Nonlinear Dynamics and Network Dynamics Group
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BCCN Kolloquium

Monday, 11.09.2006 17 c.t.

Multilevel modeling of cellular networks

by Dr. Jose Vilar
from Computational Biology Center, New York

Contact person: Theo Geisel


Seminarraum Haus 2, 4. Stock (Bunsenstr.)


The typical approach to modeling cellular networks assumes that interactions between cellular components are like chemical reactions in an ideal, well-stirred macroscopic reactor. It is now becoming increasingly evident that this approach is not sufficient to fully understand the functioning of even the simplest systems. I will show that to study the induction of the lac operon genetic system in the bacterium Escherichia coli one needs to consider explicitly the molecular, cellular, and cell population levels of organization. I will pay special attention to the intrinsic stochasticity of molecular events and how it propagates through the different levels up to the generation of behavioral diversity in the dynamics of cell populations.

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