Max Planck Institute for Dynamics and Self-Organization -- Department for Nonlinear Dynamics and Network Dynamics Group
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BCCN AG-Seminar

Monday, 26.11.2007 13 c.t.

Perisynaptic astrocyte processes: Involvement of ezrin in their formation and plasticity

by PD Dr. Amin Derouiche
from Institute for Anatomy and Cell Biology, University of Freiburg



The astroycte is considered a third partner of the synapse; particularly its extremely fine (<50nm!) peripheral astroycte process (PAP) represents the morphological correlate of glia-synaptic interaction. Although the pre- and postsynaptic elements have been described in great molecular detail relatively little is known about the PAP, owing to its hard accessibility for electrophysiology or light microscopy, since it is subresolution. We studied astrocytes in vitro and in vivo, applying deconvolution microscopy, immuno-electron microsopy and live microscopy. In asking for the stimulus and intracellular motility mechanisms guiding the PAP to the synapse, we have identified the actin-binding protein ezrin and two mGluRs. As a first selective propertiy of the PAP, ezrin is required for its motility, and glutamate can stimulate its motility through mGluR activation.

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