Max Planck Institute for Dynamics and Self-Organization -- Department for Nonlinear Dynamics and Network Dynamics Group
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BCCN/BFNT AG-Seminar

Tuesday, 09.02.2016 17 c.t.

Emergent dynamics in a reconstruction of a neocortical microcircuit

by Dr. Eilif Muller
from Ecole polytechnique fédérale de Lausanne, Blue Brain Project, Switzerland

Contact person: Viola Priesemann

Location

Ludwig Prandtl lecture hall

Abstract

I present a method for the digital reconstruction of the microcircuitry of somatosensory cortex of P14 rat from available experimental data. The reconstruction contains 55 morphological neuron types and 207 morpho-electrical sub-types distributed across 6 layers and simulated in full morphological detail. Synapse locations are determined by a "connectome algorithm" constrained and validated by a variety anatomical data. The physiology of the resulting multi-synapse connections are modeled to match a broad range of pathway-specific experimental data on synaptic physiology, correcting for space-clamp artifacts, and elevated extracellular Ca2+ concentrations in vitro. We explored the spontaneous and sensory evoked dynamics of the microcircuit, and its dependence on extracellular [Ca2+] in particular. The simulations predict [Ca2+]_ext to be an important modulator of e-i balance in the network, which we susequently confirmed in vitro. We found a sharp transition in the dynamical properties of the microcircuit around in vivo levels of [Ca2+]_ext, and found it reproduced recent in vivo experiments near this critical point without parameter tuning.

Remarks

In additional to this talk Dr. Eilif Muller will give a tutorial at 2:15 PM to which you are also invited!

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