Max Planck Institute for Dynamics and Self-Organization -- Department for Nonlinear Dynamics and Network Dynamics Group
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MPI Kolloquium

Wednesday, 22.02.2012 15:15 c.t.

Mechanochemical Pattern Generation

by Dr. Stephan Grill
from MPI of Molecular Cell Biology and Genetics, Dresden

Contact person: Fred Wolf

Location

Ludwig Prandtl lecture hall

Abstract

I will present recent advances in our understanding of the coupling of mechanical and bio-chemical processes for the purpose of forming intracellular patterns. I will begin by discussing in general terms the mechanism of pattern formation in active fluids in which active stress is regulated by diffusing molecular components. I will then discuss a biologi-cal example, which is the polarization of the C. elegans zygote, a classic example for mechanochemical coupling. Here, passive advective transport by flow of a mechanically active material acts as a trigger for pattern formation in a system of diffusing and interact-ing PAR proteins. Our work suggests that advective transport in regulated active materials is a general mechanism by which patterns are established in developmental biology. References: -N. Goehring, P. Khuc-Trong , J. S. Bois, D. Chowdhury, E. Nicola, A. A. Hyman, S. W. Grill, Polarization of PAR Proteins by Advective Triggering of a Pattern-Forming System, Science 334, 1137-1141 (2011) -J. S. Bois, F. Jülicher, S. W. Grill, Pattern formation in active fluids, Phys. Rev. Lett. 106, 28103 (2011) -M. Mayer, M. Depken, J. S. Bois, F. Jülicher, S. W. Grill, Anisotropies in cortical tension reveal the physical basis of polarizing cortical flows, Nature 467, 617-621 (2010)

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