Max Planck Institute for Dynamics and Self-Organization -- Department for Nonlinear Dynamics and Network Dynamics Group
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MPI Kolloquium

Wednesday, 26.06.2013 15 c.t.

The cell cycle and the circadian clock: Dynamics of two coupled cellular rhythms

by Prof. Dr. Albert Goldbeter
from Faculté des Sciences Université Libre de Bruxelles, Brussels, Belgium

Contact person: Theo Geisel

Location

Ludwig Prandtl lecture hall

Abstract

Oscillations arise in genetic and enzymatic networks as a result of various modes of cellular regulation. To illustrate how mathematical modeling contributes to clarify the dynamical bases of oscillatory behavior, the presentation will focus on two major cellular rhythms: the cell cycle and the circadian clock. Models of increasing complexity based on experimental observations predict the occurrence of sustained circadian oscillations that correspond to the evolution toward a limit cycle. Stochastic simulations show how circadian oscillations are affected by molecular noise. A model for the mammalian circadian clock allows us to investigate the dynamical bases of physiological disorders of the sleep-wake cycle in humans. The cell division cycle represents another major example of periodic behavior at the cellular level. A network of enzymes known as cyclin-dependent kinases (Cdks) governs progression along the successive phases of the cell cycle. A model for the Cdk network indicates that it is capable of temporal self-organization in the form of sustained oscillations, which correspond to the repetitive, transient activation of the cyclin/Cdk complexes that control the successive phases of the cell cycle. The model suggests that the transition from cellular quiescence to proliferation corresponds to the passage through a bifurcation in which a steady state loses its stability and the system evolves to a limit cycle. Several molecular components of the cell cycle network are controlled in a circadian manner. The coupling of the cell cycle to the circadian clock results in the synchronization of these two major cellular rhythms

Remarks

http://www.ulb.ac.be/sciences/utc/

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